sudo su
cd /SourceCache/php-5.2.6/ext/APC/
phpize
MACOSX_DEPLOYMENT_TARGET=10.5 CFLAGS="-arch ppc -arch ppc64 -arch i386 -arch x86_64 -g -Os  -pipe -no-cpp-precomp" CCFLAGS="-arch ppc -arch ppc64 -arch i386 -arch x86_64 -g -Os  -pipe" CXXFLAGS="-arch ppc -arch ppc64 -arch i386 -arch x86_64 -g -Os  -pipe" LDFLAGS="-arch ppc -arch ppc64 -arch i386 -arch x86_64 -bind_at_load" ./configure --target=x86_64
make
make install

cd /usr/lib/php/extensions/no-debug-non-zts-20060613/
sh-3.2# file apc.so 
apc.so: Mach-O universal binary with 4 architectures
apc.so (for architecture ppc7400):	Mach-O bundle ppc
apc.so (for architecture ppc64):	Mach-O 64-bit bundle ppc64
apc.so (for architecture i386):	Mach-O bundle i386
apc.so (for architecture x86_64):	Mach-O 64-bit bundle x86_64